09 Sep It is found usually in animal organs but occasionally in blood
Forssman antigen a heterogenetic antigen discovered in guinea pig tissues, capable of lysing sheep erythrocytes in the presence of complement. It is found usually in animal organs but occasionally in blood, and induces formation of an antibody (Forssman antibody, a type of heterophile antibody) only when combined with protein or hog serum. Davidsohn’s Differential Test was historically used to differentiate between the heterophile sheep agglutinins in human serum that were due to Forssman antigen and those due to infectious mononucleosis; this is based upon the fact that boiled guinea pig kidney will absorb heterophile sheep cell agglutinins produced by Forssman antigen, but not those produced by infectious mononucleosis..
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